Edward M Schaeffer Selected Research

Neoplasms (Cancer)

5/2022	High intratumoral plasma cells content in primary prostate cancer defines a subset of tumors with potential susceptibility to immune-based treatments.
1/2022	Association of B7-H3 expression with racial ancestry, immune cell density, and androgen receptor activation in prostate cancer.
12/2021	Somatic HOXB13 Expression Correlates with Metastatic Progression in Men with Localized Prostate Cancer Following Radical Prostatectomy.
11/2021	Novel genomic signature predictive of response to immune checkpoint blockade: A pan-cancer analysis from project Genomics Evidence Neo-plasia Information Exchange (GENIE).
10/2021	Plasma cells are enriched in localized prostate cancer in Black men and are associated with improved outcomes.
1/2021	Performance of Prostate Health Index in Biopsy Naïve Black Men.
1/2021	TMPRSS2-ERG fusion impacts anterior tumor location in men with prostate cancer.
1/2021	Comparative analysis of 1152 African-American and European-American men with prostate cancer identifies distinct genomic and immunological differences.
1/2021	A PRC2-independent function for EZH2 in regulating rRNA 2'-O methylation and IRES-dependent translation.
1/2020	Neuroendocrine differentiation in usual-type prostatic adenocarcinoma: Molecular characterization and clinical significance.

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Edward M Schaeffer Research Topics

Disease

96	Prostatic Neoplasms (Prostate Cancer) 10/2022 - 12/2008
59	Neoplasms (Cancer) 05/2022 - 05/2006
31	Neoplasm Metastasis (Metastasis) 11/2022 - 11/2007
20	Urinary Tract Infections (Urinary Tract Infection) 01/2020 - 01/2012
7	Infections 03/2022 - 01/2006
7	Adenocarcinoma 01/2020 - 05/2011
7	Margins of Excision 01/2020 - 05/2011
6	Inflammation (Inflammations) 01/2021 - 09/2012
6	Carcinoma (Carcinomatosis) 01/2020 - 07/2010
6	Prostatitis 02/2016 - 07/2012
4	Urinary Bladder Neoplasms (Bladder Cancer) 10/2018 - 09/2006
4	Hemorrhagic Cystitis 10/2018 - 12/2013
4	Disease Progression 11/2017 - 10/2011
3	Cystitis 11/2016 - 10/2012
3	Transitional Cell Carcinoma 11/2007 - 06/2007
2	Sepsis (Septicemia) 03/2022 - 05/2012
2	Bacteriuria 11/2020 - 11/2013
2	Reinfection 01/2016 - 10/2013
2	Carcinogenesis 08/2015 - 06/2012
2	Escherichia coli Infections 07/2015 - 08/2014
2	Xanthogranulomatous Pyelonephritis 09/2012 - 11/2009
2	Prostatic Hyperplasia (Benign Prostatic Hyperplasia) 09/2012 - 09/2012
2	Erectile Dysfunction 05/2012 - 04/2012
2	Kidney Neoplasms (Kidney Cancer) 07/2010 - 08/2009
2	Medullary Carcinoma 07/2010 - 08/2009
1	Hypoxia (Hypoxemia) 01/2021
1	Genomic Instability 01/2021
1	Uterine Cervical Neoplasms (Cancer of the Cervix) 03/2020
1	Chronic Pain 01/2020

Drug/Important Bio-Agent (IBA)

31	Prostate-Specific Antigen (Semenogelase)IBA 11/2022 - 04/2009
20	AndrogensIBA 05/2022 - 05/2011
15	Androgen Receptors (Androgen Receptor)IBA 01/2022 - 10/2011
13	Biomarkers (Surrogate Marker)IBA 12/2021 - 09/2006
11	Anti-Bacterial Agents (Antibiotics)IBA 03/2022 - 04/2013
10	Biological ProductsIBA 10/2022 - 10/2015
8	Proteins (Proteins, Gene)FDA Link 01/2020 - 09/2012
5	Dihydrotachysterol (AT 10)IBA 11/2016 - 09/2010
4	Messenger RNA (mRNA)IBA 01/2022 - 11/2017
4	Hormones (Hormone)IBA 12/2019 - 07/2010
3	RNA (Ribonucleic Acid)IBA 05/2022 - 01/2018
3	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 07/2010
3	Pharmaceutical PreparationsIBA 12/2019 - 06/2013
3	Phenobarbital (Luminal)FDA Link 12/2019 - 01/2016
3	Kazal Pancreatic Trypsin InhibitorIBA 12/2019 - 10/2015
3	Ciprofloxacin (Cipro)FDA LinkGeneric 01/2016 - 10/2012
3	FluoroquinolonesIBA 07/2012 - 01/2012
2	Immune Checkpoint InhibitorsIBA 11/2021 - 01/2019
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021 - 08/2011
2	enzalutamideIBA 01/2020 - 01/2016
2	acetyl- 2- naphthylalanyl- 3- chlorophenylalanyl- 1- oxohexadecyl- seryl- 4- aminophenylalanyl(hydroorotyl)- 4- aminophenylalanyl(carbamoyl)- leucyl- ILys- prolyl- alaninamide FDA Link 01/2020 - 01/2018
2	Cyclophosphamide (Cytoxan)FDA LinkGeneric 01/2020 - 10/2018
2	PlatinumIBA 11/2019 - 10/2018
2	Histones (Histone)IBA 01/2019 - 01/2017
2	Nitrofurantoin (Macrodantin)FDA LinkGeneric 12/2018 - 10/2013
2	Fosfomycin FDA Link 12/2018 - 12/2015
2	AntigensIBA 01/2018 - 08/2017
2	Levofloxacin (Levaquin)FDA Link 12/2017 - 01/2016
2	ChromatinIBA 01/2017 - 01/2017
2	Transcription Factors (Transcription Factor)IBA 01/2017 - 01/2017
2	Aligeron (AS 2)IBA 08/2015 - 05/2012
2	CytokinesIBA 02/2015 - 10/2011
2	Type II DNA Topoisomerases (Topoisomerase II)IBA 07/2010 - 08/2009
1	GenieIBA 11/2021
1	sipuleucel-T (APC8015)FDA Link 10/2021
1	Immunoglobulin G (IgG)IBA 10/2021
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2021
1	Interleukin-33IBA 01/2021
1	Internal Ribosome Entry SitesIBA 01/2021
1	Nerve Growth Factor (NGF)IBA 01/2020
1	VaccinesIBA 01/2020
1	Sodium Potassium Chloride Symporter Inhibitors (Loop Diuretics)IBA 01/2020
1	Chromogranin AIBA 01/2020
1	Androgen Antagonists (Antiandrogens)IBA 01/2020
1	abirateroneIBA 01/2020
1	Prostaglandins AIBA 01/2020
1	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 01/2020
1	Calcitonin Gene-Related PeptideIBA 01/2020
1	Histone Deacetylase InhibitorsIBA 12/2019
1	Keratins (Keratin)IBA 12/2019
1	Docetaxel (Taxotere)FDA Link 11/2019
1	Ibuprofen (Motrin)FDA LinkGeneric 10/2019
1	Amdinocillin Pivoxil (Pivmecillinam)IBA 10/2019
1	plazomicinIBA 10/2019

Therapy/Procedure

53	Prostatectomy (Retropubic Prostatectomy) 11/2022 - 12/2008
31	Therapeutics 06/2022 - 01/2009
17	Radiotherapy 12/2021 - 01/2016
10	Castration 05/2022 - 12/2016
6	Antibiotic Prophylaxis 03/2022 - 06/2012
5	Drug Therapy (Chemotherapy) 11/2019 - 01/2016
3	Immunotherapy 05/2022 - 01/2019
3	Stents 11/2020 - 01/2018
3	Cystectomy 12/2019 - 10/2018
3	Lymph Node Excision (Lymph Node Dissection) 01/2018 - 03/2005
3	Nephrectomy 09/2012 - 01/2009
3	Nephroureterectomy 11/2007 - 06/2007
2	Lithotripsy (Extracorporeal Shockwave Lithotripsy) 01/2020 - 12/2017
2	Cryosurgery 01/2018 - 05/2006
2	Hematopoietic Stem Cell Transplantation 03/2016 - 12/2013
2	Catheters 01/2016 - 05/2013
1	Minimally Invasive Surgical Procedures 03/2020